diff --git a/drivers/tty/serial/stm32-usart.c b/drivers/tty/serial/stm32-usart.c
index 370141445780..326f300dd410 100644
--- a/drivers/tty/serial/stm32-usart.c
+++ b/drivers/tty/serial/stm32-usart.c
@@ -218,9 +218,6 @@ static void stm32_usart_receive_chars(struct uart_port *port, bool threaded)
 	u32 sr;
 	char flag;
 
-	if (irqd_is_wakeup_set(irq_get_irq_data(port->irq)))
-		pm_wakeup_event(tport->tty->dev, 0);
-
 	if (threaded)
 		spin_lock_irqsave(&port->lock, flags);
 	else
@@ -463,6 +460,7 @@ static void stm32_usart_transmit_chars(struct uart_port *port)
 static irqreturn_t stm32_usart_interrupt(int irq, void *ptr)
 {
 	struct uart_port *port = ptr;
+	struct tty_port *tport = &port->state->port;
 	struct stm32_port *stm32_port = to_stm32_port(port);
 	const struct stm32_usart_offsets *ofs = &stm32_port->info->ofs;
 	u32 sr;
@@ -473,9 +471,14 @@ static irqreturn_t stm32_usart_interrupt(int irq, void *ptr)
 		writel_relaxed(USART_ICR_RTOCF,
 			       port->membase + ofs->icr);
 
-	if ((sr & USART_SR_WUF) && ofs->icr != UNDEF_REG)
+	if ((sr & USART_SR_WUF) && ofs->icr != UNDEF_REG) {
+		/* Clear wake up flag and disable wake up interrupt */
 		writel_relaxed(USART_ICR_WUCF,
 			       port->membase + ofs->icr);
+		stm32_usart_clr_bits(port, ofs->cr3, USART_CR3_WUFIE);
+		if (irqd_is_wakeup_set(irq_get_irq_data(port->irq)))
+			pm_wakeup_event(tport->tty->dev, 0);
+	}
 
 	if ((sr & USART_SR_RXNE) && !(stm32_port->rx_ch))
 		stm32_usart_receive_chars(port, false);
@@ -901,6 +904,12 @@ static void stm32_usart_set_termios(struct uart_port *port,
 		cr1 &= ~(USART_CR1_DEDT_MASK | USART_CR1_DEAT_MASK);
 	}
 
+	/* Configure wake up from low power on start bit detection */
+	if (stm32_port->wakeirq > 0) {
+		cr3 &= ~USART_CR3_WUS_MASK;
+		cr3 |= USART_CR3_WUS_START_BIT;
+	}
+
 	writel_relaxed(cr3, port->membase + ofs->cr3);
 	writel_relaxed(cr2, port->membase + ofs->cr2);
 	writel_relaxed(cr1, port->membase + ofs->cr1);
@@ -1476,23 +1485,20 @@ static void __maybe_unused stm32_usart_serial_en_wakeup(struct uart_port *port,
 {
 	struct stm32_port *stm32_port = to_stm32_port(port);
 	const struct stm32_usart_offsets *ofs = &stm32_port->info->ofs;
-	const struct stm32_usart_config *cfg = &stm32_port->info->cfg;
-	u32 val;
 
 	if (stm32_port->wakeirq <= 0)
 		return;
 
+	/*
+	 * Enable low-power wake-up and wake-up irq if argument is set to
+	 * "enable", disable low-power wake-up and wake-up irq otherwise
+	 */
 	if (enable) {
-		stm32_usart_clr_bits(port, ofs->cr1, BIT(cfg->uart_enable_bit));
 		stm32_usart_set_bits(port, ofs->cr1, USART_CR1_UESM);
-		val = readl_relaxed(port->membase + ofs->cr3);
-		val &= ~USART_CR3_WUS_MASK;
-		/* Enable Wake up interrupt from low power on start bit */
-		val |= USART_CR3_WUS_START_BIT | USART_CR3_WUFIE;
-		writel_relaxed(val, port->membase + ofs->cr3);
-		stm32_usart_set_bits(port, ofs->cr1, BIT(cfg->uart_enable_bit));
+		stm32_usart_set_bits(port, ofs->cr3, USART_CR3_WUFIE);
 	} else {
 		stm32_usart_clr_bits(port, ofs->cr1, USART_CR1_UESM);
+		stm32_usart_clr_bits(port, ofs->cr3, USART_CR3_WUFIE);
 	}
 }